CBD FOR STRESS & ANXIETY

CBD FOR GENERAL ANXIETY

A 2019 study set out to determine whether CBD helps improve sleep and/or anxiety. It used a large sample size of 72 patients with primary concerns of anxiety (47 patients) and poor sleep (25 patients).  Anxiety scores decreased within the first month in 57 patients (79.2%) and remained decreased during the entire study.  Sleep scores improved within the first month in 48 patients (66.7%).  CBD was well tolerated in all but 3 patients. (SOURCE).

A 2018 study reviewed the clinical studies investigating the use of CBD as a treatment of psychiatric symptoms. The findings to date suggest that CBD has the ability to reduce psychotic, anxiety and withdrawal symptoms by means of several hypothesized pharmacological properties.  (SOURCE).

A 2015 review found that existing preclinical evidence strongly supports CBD as a treatment for generalized anxiety disorder, panic disorder, social anxiety disorder, obsessive-compulsive disorder, and post-traumatic stress disorder when administered acutely. The review also found that evidence from human studies supports an anxiolytic role of CBD.  The review concluded that current evidence indicates CBD has considerable potential as a treatment for multiple anxiety disorders. (SOURCE).

Another study from 2015 showed that CBD improved anxiety compared with a placebo during a simulated public speaking test. (SOURCE).

Anxiety and depression are pathologies that affect people in many aspects of life, including social life, productivity and health. A 2014 reviewed studies of animal models using CBD as an anxiolytic-like and antidepressant-like compound.  Experiments with CBD demonstrated non-activation of neruoreceptors CB1 and CB2.  Most of the studies reviewed demonstrated good interaction between CBD and 5-HT1A neuro-receptor.  (SOURCE).

Animal and human studies indicate that CBD has anxiolytic properties. A study published in 2010 investigated the effects of CBD on human pathological anxiety and its underlying brain mechanisms in patients with generalized social anxiety disorder (SAD) using functional neuroimaging.  The results suggest that CBD reduces anxiety in SAD because of its effects on activity in limbic and paralimbic brain areas.  (SOURCE).

Anxiety and sleep disorders are often the result of posttraumatic stress disorder and can contribute to an impaired ability to focus and to demonstration of oppositional behaviors. A 2016 case study evaluated a patient with these symptoms.  Pharmaceutical medications provided partial relief, but results were not long-lasting and there were major side-effects.  This case study provides clinical data that support the use of CBD as a safe treatment for reducing anxiety and improving sleep in a young girl with PTSD.  (SOURCE)

A 2016 investigated the potential involvement of hippocampal neurogenesis in the anxiolytic effect of CBD in mice. The findings in the study support that the anxiolytic effect of chronic CBD administration in stressed mice depends on its proneurogenic action in the adult hippocampus by facilitating endocannabinoid-mediated signaling.  (SOURCE)

CBD FOR PUBLIC SPEAKING

Fear of public speaking (Glossophobia) is very common and is experienced by most of us. A study published in 2017 investigated the benefits of CBD at various dosage amounts.  60 healthy individuals between the age of 18 and 35 were randomly assigned to five groups.  One group received a placebo.  Once group received 1mg of clonazepam.  One group received 100mg of CBD.  Another group received 300mg of CBD.  The final group received 900mg of CBD.  Each group underwent a test of public speaking and answered a questionnaire and recorded their vitals.  The results showed that CBD at a dosage of 300mg significantly reduced anxiety in the post speech phase, but the same was not true for 100mg or 900mg.  (SOURCE). This indicates that users a higher dosage doesn’t necessarily translate to faster or better results.

Olakino believes the key to long-term wellness is an accurate daily dose. Every person’s accurate dose might differ, which is why starting with small, but realistic doses is the what we recommend.

Generalized Social Anxiety Disorder (SAD) is one of the most common anxiety conditions with impairment in social life. CBD has shown anxiolytic effects both in humans and in animals.  A study published in 2011 aimed to compare the effects of a simulation public speaking test (SPST) on healthy control (HC) patients and treatment- naïve SAD patients who received a single dose of CBD or placebo.  A total of 24 never-treated patients with SAD.  12 patients were given to 600mg of CBD and 12 patients were given a placebo in a double-blind randomized design 90 minutes before a speaking test.  The results showed that pretreatment with CBD significantly reduced anxiety, cognitive impairment and discomfort in their speech performance, and significantly decreased alert in their anticipatory speech.   The placebo group presented higher anxiety, cognitive impairment and discomfort.  The study concluded that anxiety induced by public speaking on subjects with SAD was reduced with the use of CBD.  (SOURCE)

CBD FOR PANIC ATTACKS

Panic Disorder (PD) is a disabling psychiatry condition that affects approximately 5% of the entire worldwide population.  The initial treatment recommended are selective serotonin reuptake inhibitors (SSRIs), but there are common side-effects that may provoke patients to abandon this treatment.

A 2017 study clearly found CBD to be a promising treatment of panic disorders because of its anxiolytic-like effect of CBD. The most compelling conclusion from the study was that CBD is not habit-forming and doesn’t decrease tolerance.  (SOURCE).  This means patients can maintain a consistent dose without building up a tolerance that requires higher strengths.

CBD FOR POST-TRAUMATIC STRESS DISORDER (PTSD)

Over 25 million people in the U.S. will experience PTSD at some point in their lives.

A 2017 study looked at how CBD might weaken fear-response related to an adverse memory (like PTSD). The results suggest CBD disrupted consolidation (memory strengthening) of specific and long-term fear memory.  CBD was also found to disrupt the consolidation of generalize fear memories when administered immediately after the acquisition of such fear memory.  Interestingly, timing of the CBD dose was vital as the results showed that delayed administration of the CBD dose did not have the same effective results that immediate dosing had. (SOURCE).

A 2019 8-week case study examined the clinical benefit of oral CBD administration of symptoms of PTSD. From the total sample of 11 patients, 91% (10 patients) experienced a decreased in PTSD symptom severity.  CBD was generally well tolerated, and no patients discontinued treatment due to side effects.  (SOURCE).

CBD FOR DEPRESSION

A 2018 review looked at the development of the clinical use of CBD. The results showed CBD to have anxiolytic, antipsychotic and neuroprotective properties.  It also indicated that CBD could be have potential use in epilepsy, substance abuse and dependence, schizophrenia, social phobia, post-traumatic stress, depression, bipolar disorder, sleep disorders and Parkinson.  (SOURCE).

A 2014 study reviewed studies of animal models using CBD as an anxiolytic-like and antidepressant-like compound. Experiments with CBD demonstrated non-activation of neuroreceptors CB1 and CB2, and most of the studies demonstrated a good interaction between CBD and 5-HT1A neuro-receptor. (SOURCE).

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