CBD FOR STEM CELLS
Mesenchymal stem cells (MSCs) have become a promising tool for the treatment of several neurodegenerative disorders, including Alzheimer’s disease (AD). The therapies for AD are limited so researchers have begun to look at CBD. A 2017 study demonstrated that GMSCs (MSCs derived from gingiva) preconditioned with CBD have better therapeutic potential compared to CTR-GMSCs (control GMSCs). (SOURCE). More research is needed, but this study suggests that GMSCs preconditioned with CBD might be beneficial for the treatment of AD.
All mesenchymal stem cells show self-renewal, clonogenicity, and multi-tissue differentiation properties and can represent a valid support for regenerative medicine. The possibility to extend MSC survival is essential to the success of stem-cell therapy. A 2018 study showed that stem cells pretreated with a combination of CBD and Moringin could improve their survival in the re-implanted tissue as a well as their differentiation capacity. This study also showed that CBD and MOR improved survival characteristics compared to untreated cells. (SOURCE).
Recruitment of mesenchymal stem cells (MSCs) to an injury site and their differentiation into the desired cell lineage are connected with deficient bone regeneration. With no ideal structure to provide these regenerative conditions so a 2019 aimed to create a new scaffold that induces MSC migration towards the defect site, followed by their differentiation into an osteogenic lineage. An in vitro migration assay showed that CBD considerably increased MSCs migration, and qRT-PCR results demonstrated upregulated expression of osteogenic markers in the presence of CBD. The results of this fascinating study concluded that CBD improved bone healing and showed a critical role for MSC migration in the bone regeneration process. (SOURCE).
Migration and differentiation of mesenchymal stem cells (MSCs) are known to be involved in various regenerative processes such as bone healing. A 2014 study found CBD increased the migration of adipose-derived MSCs. Collectively, this study demonstrates CBD to promote the migration of MSCs via activation of the CB₂ receptor and inhibition of GPR55 and to induce osteoblastic differentiation. CBD may therefore recruit MSCs to sites of calcifying tissue regeneration and subsequently support bone regeneration via an osteoanabolic action on MSCs. (SOURCE).